AVA6000 set to start US Phase I studies in early-2022
Lighthouse | 29 November 2021
Trinity Delta view: The extension of the AVA6000 Phase I study into the US, ahead of our expectations, is an endorsement of Avacta’s clinical team’s efforts and the quality of the preclinical package. Positive outcomes in reducing doxorubicin’s systemic toxicity will be important in establishing proof of concept of the pre|CISION platform. A broader pipeline of pro-drugs whose clinical utility would benefit from improved efficacy and reduced toxicities is being progressed. We value Avacta at £710m, or 280p per share, with the Diagnostic opportunities representing £133m and the Therapeutic pipeline rNPV £559m.
29 November 2021
Avacta owns two novel technology platforms: Affimer and pre|CISION. Affimer proteins are antibody mimetics being developed as diagnostic reagents and oncology therapeutics. pre|CISION improves potency and reduces toxicity of cancer drugs by only activating them inside the tumour. Successful clinical trials would be transformative for Avacta.
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