Further support for bemcentinib’s broad potential from preclinical data at AACR
Lighthouse | 1 April 2019
Trinity Delta view: These new data lend further support to the broad potential of bemcentinib in different settings and its proposed mode of action in reversing immune suppression and therapy resistance. The results from the preclinical studies with NSCLC models provide further scientific rationale for combining bemcentinib with PD1/PD-L1 inhibitors, as well as opening-up a potential new setting for bemcentinib in combination with DDR agents. Similarly, the data from the pancreatic cancer studies lend support to the use of bemcentinib in this indication.
Our valuation of BerGenBio is NOK3,143m ($370m) or NOK57.45/share. The next significant catalysts for the shares are expected to be overall survival data from the first stage of the Phase II study in NSCLC with pembrolizumab and the results from the trial’s second stage, both of which should be reported in Q219.
1 April 2019
BerGenBio is a clinical-stage, drug development company based in Bergen, Norway and Oxford, UK. It is developing innovative anti-cancer therapies that act on the promising Axl signalling pathway. The lead oncology compound, bemcentinib, is in a number of Phase II trials.
Mick Cooper PhD
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