Phase II melanoma study with SCIB1 to start in Q219
Lighthouse | 25 April 2019
Trinity Delta view: SCIB1 as monotherapy (administered with a previous generation of the Ichor system) has already delivered promising results in the Phase I/II study in melanoma, with one of the 15 patients achieving a partial response (still alive after 5 years) and two achieving stable disease (still alive after 2 years), and was well tolerated. However, the standard of care for melanoma patients is now to be treated with checkpoint inhibitors, such as pembrolizumab, and this trial is important for providing a route to market. We also anticipate that SCIB1 will prove to work synergistically with pembrolizumab. The first data from the trial will probably be available in H120.
It is disappointing, though unsurprising, that discussions with the FDA are still ongoing as this will be the first clinical trial in the US that delivers SCIB1 using the TriGrid v2.0 system, although it has been used in other trials outside the US.
We value Scancell at £82.0m, equivalent to 21.1p a share.
25 April 2019
|Primary exchange||AIM London|
Scancell is a clinical-stage immuno-oncology specialist that is developing two innovative and flexible therapeutic vaccine platforms. ImmunoBody and Moditope induce high avidity cytotoxic CD8 and CD4 responses, respectively, with the potential to treat various cancers.
Mick Cooper PhD
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